#ifndef VIENNA_RNA_PACKAGE_MEA_H #define VIENNA_RNA_PACKAGE_MEA_H #include #include /** * @file MEA.h * @ingroup subopt_and_representatives * @brief Computes a MEA (maximum expected accuracy) structure. */ /** * @brief Computes a MEA (maximum expected accuracy) structure. * * @ingroup mea_fold * * The algorithm maximizes the expected accuracy * @f[ A(S) = \sum_{(i,j) \in S} 2 \gamma p_{ij} + \sum_{i \notin S} p^u_i @f] * Higher values of @f$\gamma@f$ result in more base pairs of lower * probability and thus higher sensitivity. Low values of @f$\gamma@f$ result in structures * containing only highly likely pairs (high specificity). * The code of the MEA function also demonstrates the use of sparse dynamic * programming scheme to reduce the time and memory complexity of folding. */ float MEA(plist *p, char *structure, double gamma); float MEA_seq(plist *p, const char *sequence, char *structure, double gamma, vrna_exp_param_t *pf); #endif