# PAM 250 matrix recommended by Gonnet, Cohen & Benner
# Science June 5, 1992.
# Values rounded to nearest integer
   C  S  T  P  A  G  N  D  E  Q  H  R  K  M  I  L  V  F  Y  W  X  *
C 12  0  0 -3  0 -2 -2 -3 -3 -2 -1 -2 -3 -1 -1 -2  0 -1  0 -1 -3 -8
S  0  2  2  0  1  0  1  0  0  0  0  0  0 -1 -2 -2 -1 -3 -2 -3  0 -8
T  0  2  2  0  1 -1  0  0  0  0  0  0  0 -1 -1 -1  0 -2 -2 -4  0 -8
P -3  0  0  8  0 -2 -1 -1  0  0 -1 -1 -1 -2 -3 -2 -2 -4 -3 -5 -1 -8
A  0  1  1  0  2  0  0  0  0  0 -1 -1  0 -1 -1 -1  0 -2 -2 -4  0 -8
G -2  0 -1 -2  0  7  0  0 -1 -1 -1 -1 -1 -4 -4 -4 -3 -5 -4 -4 -1 -8
N -2  1  0 -1  0  0  4  2  1  1  1  0  1 -2 -3 -3 -2 -3 -1 -4  0 -8
D -3  0  0 -1  0  0  2  5  3  1  0  0  0 -3 -4 -4 -3 -4 -3 -5 -1 -8
E -3  0  0  0  0 -1  1  3  4  2  0  0  1 -2 -3 -3 -2 -4 -3 -4 -1 -8
Q -2  0  0  0  0 -1  1  1  2  3  1  2  2 -1 -2 -2 -2 -3 -2 -3 -1 -8
H -1  0  0 -1 -1 -1  1  0  0  1  6  1  1 -1 -2 -2 -2  0  2 -1 -1 -8
R -2  0  0 -1 -1 -1  0  0  0  2  1  5  3 -2 -2 -2 -2 -3 -2 -2 -1 -8
K -3  0  0 -1  0 -1  1  0  1  2  1  3  3 -1 -2 -2 -2 -3 -2 -4 -1 -8
M -1 -1 -1 -2 -1 -4 -2 -3 -2 -1 -1 -2 -1  4  2  3  2  2  0 -1 -1 -8
I -1 -2 -1 -3 -1 -4 -3 -4 -3 -2 -2 -2 -2  2  4  3  3  1 -1 -2 -1 -8
L -2 -2 -1 -2 -1 -4 -3 -4 -3 -2 -2 -2 -2  3  3  4  2  2  0 -1 -1 -8
V  0 -1  0 -2  0 -3 -2 -3 -2 -2 -2 -2 -2  2  3  2  3  0 -1 -3 -1 -8
F -1 -3 -2 -4 -2 -5 -3 -4 -4 -3  0 -3 -3  2  1  2  0  7  5  4 -2 -8
Y  0 -2 -2 -3 -2 -4 -1 -3 -3 -2  2 -2 -2  0 -1  0 -1  5  8  4 -2 -8
W -1 -3 -4 -5 -4 -4 -4 -5 -4 -3 -1 -2 -4 -1 -2 -1 -3  4  4 14 -4 -8
X -3  0  0 -1  0 -1  0 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -2 -2 -4 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1